¡¡
¡¡
¡¡
Abstract
¡¡
Vol 47 No. 3: 214-223 [PDF] [Full Text]
¡¡
STK33 plays an important positive role in the development of human large cell lung cancers with variable metastatic potential
¡¡
Ping Wang, Hongzhong Cheng, Jianqiang Wu, Anrun Yan and Libin Zhang*
¡¡
Department of Thoracic Surgery, First People's Hospital of Yunnan Province, Kunming 650031, China
¡¡

Abstract  Serine/threonine kinase 33 (STK33) is a novel protein that has attracted considerable interest in recent years. Previous research has revealed that STK33 expression plays a special role in cancer cell proliferation. However, the mechanisms of STK33 induction of cancer cells remain largely unknown. In this study, it is demonstrated that STK33 expression varies in NL9980 and L9981 cells which are homogeneous cell lines with similar genetic backgrounds. STK33 can promote cell migration and invasion and suppress p53 gene expression in the NL9980 and L9981 cells. In addition, this protein also promotes epithelial¨Cmesenchymal transition (EMT). Moreover, STK33 knockdown decreases tumor-related gene expression and inhibits cell migration, invasion, and EMT, suggesting that STK33 may be a mediator of signaling pathways that are involved in cancer. In conclusion, our results suggest that STK33 may be an important prognostic marker and a therapeutic target for the metastatic progression of human lung cancer.

¡¡

Keywords   STK33; epithelial¨Cmesenchymal transition; proliferation; human large cell lung cancer

¡¡

Received   2014-9-20¡¡¡¡
Accepted  
2014-12-10

¡¡

Funding  This work was supported by a grant from the Science and Technology Department of Yunnan province (No. 2012FB093).

¡¡

* Correspondence address  Tel: +86-871-63638675; E-mail: [email protected]

¡¡
Browse:193
¡¡
Manuscript Submission

    ScholarOne Manuscripts

User ID

Password

           

    Password Help

E-Mail

¡¡
¡¡
Copyright 1999-2015    Acta Biochimica et Biophysica Sinica    All Rights Reserved
Address: Room 407, Building 31B, 319 Yueyang Road, Shanghai, 200031 P.R. China
Fax: 86-21-54920954    Email: [email protected]
¡¡
»¦ICP±¸05033115ºÅ  |   ÄúÊÇµÚ Î»·ÃÎÊÕߣ¬»¶Ó­£¡