Abstract
 
Vol 47 No. 7: 557-563 [PDF] [Full Text]
 
Differential expression of bone morphogenetic protein 5 in human lung squamous cell carcinoma and adenocarcinoma
 
Taoran Deng1,2,†, Dandan Lin3,†, Man Zhang4, Qingchuan Zhao4, Weina Li5, Bo Zhong4, Yu Deng1,* and Xiangning Fu1,*

1Department of Thoracic Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
2The Second Clinical Medical Department, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
3Department of Oncology, Renmin Hospital of Wuhan University, Wuhan University, Wuhan 430060, China
4State Key Laboratory of Virology, College of Life Science, Wuhan University, Wuhan 430072, China
5Department of Infectious Disease, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
These authors contributed equally to this work.
 

Abstract  Bone morphogenetic proteins (BMPs) play important roles in tumor cell proliferation, metastasis, and invasion. However, the expression patterns of BMPs in patients with non-small-cell lung cancer (NSCLC) and their correlations with NSCLC pathogenesis have not been examined yet. In this study, the mRNA levels of BMP family members in NSCLC tissues were analyzed and results showed that the mRNA levels of BMP5 and BMP7 were significantly down-regulated and up-regulated, respectively, in tumor tissues compared with those in the corresponding noncancerous tissues. Interestingly, the mRNA level of BMP5 was significantly higher in lung adenocarcinoma tissues than that in lung squamous cell carcinoma tissues. Furthermore, results from immunohistochemistry analysis confirmed stronger expression of BMP5 protein in lung adenocarcinoma than in lung squamous cell carcinoma. Our findings suggested that BMP5 might be a potential prognostic biomarker or therapeutic target for patients with NSCLC.

 

Keywords   non-small-cell lung cancer; adenocarcinoma; squamous cell carcinoma; bone morphogenetic protein; prognostic biomarker

 

Received   2015-2-2  
Accepted  
2015-3-10

 

Funding  This work was supported by the grants from Natural Science Foundation of China (Nos. 81301505 and 31371427), Ministry of Education of China (Nos. 201427 and 2042014kf0145), and Large-scale Instrument and Equipment Sharing Foundation of Wuhan University.

 

* Correspondence address  Tel/Fax: +86-27-83646605; E-mail: fuxn2006@aliyun.com (X.F.)/leojokea@aliyun.com (Y.D.)

 
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