Vol 47 No. 8: 571-580 [PDF] [Full Text]
The receptor proteins: pivotal roles in selective autophagy
Zhijie Xu1,2,3, Lifang Yang1,2,3,*, San Xu1,2,3, Zhibao Zhang1,2,3 and Ya Cao1,2,3

1Cancer Research Institute, Central South University, Changsha 410078, China
2Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Changsha 410078, China
3Key Laboratory of Carcinogenesis, Ministry of Health, Changsha 410078, China

Abstract  Autophagy is a highly regulated and multistep biological process whereby cells under metabolic, proteotoxic, or other stresses remove dysfunctional organelles and/or misfolded/polyubiquitinated proteins by shuttling them via specialized structures called autophagosomes to the lysosome for degradation. Although autophagy is generally considered to be a non-selective process, accumulating evidence suggests that it can also selectively degrade specific target cargoes. These selective targets include proteins, mitochondria, and even invading bacteria. The discovery and characterization of autophagic adapters, such as p62/Sequestosome 1 (SQSTM1) and Neighbor of BRCA1 gene 1 (NBR1), have provided mechanistic insights into selective autophagy. These receptors are all able to act as cargo receptors for the degradation of ubiquitinated substrates. This review mainly summarizes the most up-to-date findings regarding the key receptor proteins that play important roles in regulating selective autophagy.


Keywords   autophagy; selective; receptor proteins


Received   2015-1-5  


Funding  This work was supported by the grants from the National Natural Science Foundation of China (No. 81372182), the China Postdoctoral Science Foundation (No. 2012T50712), the Hunan Provincial Innovation Foundation for Postgraduate (No. 71380100003), and the


* Correspondence address  Tel: +86-731-84805448; Fax: +86-731-84470589; E-mail: yanglifang@csu.edu.cn

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