| |
 |
Abstract |
|
| |
| Vol 48 No. 2: 194-201 |
[PDF] [Full Text] |
| |
| Transforming growth factor-beta increases breast cancer stem cell population partially through upregulating PMEPA1 expression |
| |
| Zhi Nie1,2,†,
Chunyan Wang3,†,
Zhongmei Zhou4,
Ceshi Chen4,
Rong Liu4,* and
Dianhua Wang1,*
|
1Pharmaceutical College of Kunming Medical University, Kunming 650500, China
2Department of Neurology, First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan 650032, China
3Department of Pathology, First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan 650032, China
4Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China
† These authors contributed equally to this work. |
| |
Abstract The prostate transmembrane protein, androgen-induced 1 (PMEPA1) has been previously shown to promote solid malignancies in a variety of cancers, but the role and mechanisms of PMEPA1 in breast cancer has not been fully addressed. Here, we found that PMEPA1 was upregulated in breast cancer cell lines as well as in a set of clinical invasive breast ductal carcinomas. Interestingly, depletion of PMEPA1 decreased breast cancer stem cell (CSC)-enriched populations, while ectopic overexpression of PMEPA1 increased breast CSC-enriched populations. Furthermore, transforming growth factor-β (TGF-β) treatment was also found to upregulate PMEPA1 expression and the CSC-enriched populations in triple-negative breast cancer cell lines. TGF-β-induced PMEPA1 expression partially contributed to TGF-β-induced breast CSC maintenance. These findings suggest that TGF-β-PMEPA1 axis might provide new diagnosis and therapeutic targets for breast cancer treatment. |
| |
Keywords PMEPA1; TGF-β; cancer stem cell |
| |
Received 2015-8-1
Accepted 2015-9-21 |
| |
Funding This study was supported by the grants from the National Natural Science Foundation of China (Nos. 81272930, 81322038, 31260208, 81460401, and U1132605), Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Me |
| |
* Correspondence address Tel: +86-871-65324888; Fax: +86-871-65336015; E-mail: [email protected] (D.W.)/Tel: +86-871-5181945; Fax: +86-871-65181945; E-mail: [email protected] (R.L.) |
| |
| Browse:201 |
|
 |
|
|
| Manuscript Submission |
|
|
 |
|
|
位访问者，欢迎！