Vol 49 No. 4: 289-301 [PDF] [Full Text]
Chemical strategies for pancreatic β cell differentiation, reprogramming, and regeneration
Xiaojie Ma and Saiyong Zhu*
Life Sciences Institute, Zhejiang University, Hangzhou 310058, China

Abstract  Generation of unlimited functional pancreatic β cells is critical for the study of pancreatic biology and treatment of diabetes mellitus. Recent advances have suggested several promising directions, including directed differentiation of pancreatic β cells from pluripotent stem cells, reprogramming of pancreatic β cells from other types of somatic cells, and stimulated proliferation and enhanced functions of existing pancreatic β cells. Small molecules are useful in generating unlimited numbers of functional pancreatic cells in vitro and could be further developed as drugs to stimulate endogenous pancreatic regeneration. Here, we provide an updated summary of recent major achievements in pancreatic β cell differentiation, reprogramming, proliferation, and function. These studies will eventually lead to significant advances in the field of pancreatic biology and regeneration.


Keywords   pancreatic β cell, small molecule, differentiation, reprogramming, regeneration


Received   2016-12-1  


Funding  This work was supported by the grants from the National Key Research and Development Program of China (No. 2016YFC1305300) and the Outstanding Youth Fund of Zhejiang Province (No. R17C120002). S.Z. is a scholar of the National 100 Young Talents Program.


* Correspondence address  Tel/Fax: +86-571-88981797; E-mail: saiyong@zju.edu.cn

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