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ISSN 1672-9145                                                 Acta Biochim Biophys Sin 2004, 36(9): 597–602                                                     CN 31-1940/Q

Association between Alcohol, Smoking and HLA-DQA1*0201 Genotype in Psoriasis

 

Guang-Yong ZHENG1,2#, Sheng-Cai WEI3#, Tie-Liu SHI1, and Yi-Xue LI1*

 

1Bioinformatics Center, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Graduate School of the Chinese Academy of Sciences, Shanghai 200031, China;
 2Research Center for Proteome Analysis, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Graduate School of the Chinese Academy of Sciences, Shanghai 200031, China;
 3Guangzhou Institute of Dermatology, Guangzhou 510095, China

 

Abstract        Psoriasis is a chronic skin disease triggered by genetic, environment or other risk factors such as infection, drugs, stress, moisture, alcohol, and smoking. A major psoriasis susceptibility locus at 6p21.3 has been identified. Further studies found that HLA-DQA1*0201 allele was associated with psoriasis. However, there were few data exploring an association between the environmental factors and susceptibility genes. In this study, the samples of 189 patients with psoriasis and 333 healthy controls were collected with their consent and were carried on analysis through polymerase chain reaction sequence-specific primer (PCR-SSP) method. The proportion of male psoriasis patients engaging in the smoking and alcohol was much higher than that of the control group (P<0.005). The HLA-DQA1*0201 allele was present at significantly higher frequency in the patients with psoriasis (OR=4.25, P<1.0´10-6). Association was found between smoking, alcohol and HLA-DQA1*0201 in male patients with psoriasis (OR>6.91, P<1.0´10-4).

 

Key words        psoriasis; HLA-DQA1*0201 allele; smoking; alcohol; association

 

 

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Received: June 9, 2004         Accepted: July 22, 2004

This work was supported by the grants from the High-Tech Research and Development Program of China (No. 2003AA231011) and the National Basic Research Program of China (No. 2003CB715901, No. 001CB510209)

#These authors contributed equally to this work

*Corresponding author: Tel, 86-21-54920089; Fax, 86-21-54920089; E-mail, [email protected]