Vol44 No.11: 897-901
Post-translational regulation of FOXO
Qi Xie1, Jing Chen2, and Zengqiang Yuan1*
(1 State Key Laboratory of Brain and Cognitive Sciences, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China; 2 College of Life Science, University of Science and Technology of China, Hefei 230027, China)
Abstract
The Forkhead box O (FOXO) family transcription factors play critical roles in a series of cellular processes, including the cell cycle, cell death, metabolism, and oxidative stress resistance. FOXO proteins are subject to several post-translational modifications, which are closely related to their activity. In this paper, we review the post-translational modifications of FOXOs and their biological functions.
Received: 2012-6-19 Accepted: 2012-7-16
*Corresponding author . Tel/Fax: +86-10-64867137; E-mail: [email protected]
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