Bo Zhong2,*
2State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan 430072, China
Abstract Host pattern-recognition receptors (PRRs) recognize pathogen-associated molecular patterns generated by invading viruses and initiate a series of signaling cascades that lead to the activation of interferon-regulatory factor 3 (IRF3) and nuclear factor-κB (NF-κB) and subsequent induction of type I interferons (IFNs). Posttranslational modification of proteins by ubiquitin plays an essential role in mediating or regulating the virus-triggered PRRs-mediated signaling. Deubiquitination is the reversible process of ubiquitination and its role in regulating PRRs-mediated signaling has recently been explored. In this review, we first summarize the ubiquitination events in PRRs-mediated signaling that is triggered by viral nucleic acid and then focus on host and viral deubiquitinating enzymes-mediated regulation of virus-triggered signaling that modulates the activation of IRF3 and NF-κB and subsequent induction of type I IFNs.
Keywords ubiquitin modification; pattern-recognition receptor; cellular innate antiviral signaling
Received 2014-12-10
Accepted 2014-12-28
Funding This study was supported by the grants from the Ministry of Science and Technology of China (No. 2014CB540600), the National Natural Science Foundation of China (No. 31371427), and the Ministry of Education of China.
* Correspondence address Tel: +86-27-68752202; Fax: +86-27-68752246; E-mail: [email protected]