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Abstract |
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| Vol 47 No. 3: 224-229 |
[PDF] [Full Text] |
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| Identification of differentially expressed miRNAs in mouse spinal cord development |
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| Botao Zhao1,
Menggui Huang2,
Yanyan Bai3,
Chunsun Fan4,
Yi Fan2,* and
Youxin Jin1,5,*
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1School of Life Sciences, Shanghai University, Shanghai 200444, China
2Department of Radiation Oncology, University of Pennsylvania, Philadelphia, PA 19104, USA
3Department of Neurology, The Affiliated Jiangyin Hospital of Southeast University Medical College, Jiangyin 214400, China
4Department of Etiology, Qidong Liver Cancer Institute, Qidong 226200, China
5State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China
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Abstract MicroRNAs (miRNAs) are a class of non-coding, regulatory small RNAs of ∼22 nt. It was implicated that these small RNAs play critical roles in various important biological processes. During development, some miRNAs are specifically expressed in individual tissues and at particular developmental stages. Many miRNAs show distinct expression patterns in the development of central nervous system, including spinal cord. In this study, we first reported the miRNAs expression in the development of mouse spinal cord. Differentially expressed miRNAs in embryonic (day 13.5) and neonatal mice spinal cords were identified. The predicted target genes of the differentially expressed miRNAs were subject to gene ontology and KEGG pathway analysis, and several nervous development-related pathways were enriched, implying that these miRNAs may be involved in these pathways that regulate mouse spinal cord development. |
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Keywords miRNA; spinal cord development; miRNA microarray |
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Received 2014-11-10
Accepted 2015-1-6 |
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Funding This work was supported by the grants from the National Key Research and Development Program of China (No. 2011CB811304), the National Natural Science Foundation of China (No. 31170750), the National Natural Science Foundation for Young Scholar (No. 31100 |
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* Correspondence address Tel: +86-21-54921222; Fax: +86-21-54921011; E-mail: [email protected] (Y.J.)/ Tel: +1-215-9899291; E-mail: [email protected] (Y.F.) |
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