Abstract
 
Vol 48 No. 2: 194-201 [PDF] [Full Text]
 
Transforming growth factor-beta increases breast cancer stem cell population partially through upregulating PMEPA1 expression
 
Zhi Nie1,2,†, Chunyan Wang3,†, Zhongmei Zhou4, Ceshi Chen4, Rong Liu4,* and Dianhua Wang1,*

1Pharmaceutical College of Kunming Medical University, Kunming 650500, China
2Department of Neurology, First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan 650032, China
3Department of Pathology, First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan 650032, China
4Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China
These authors contributed equally to this work.
 

Abstract  The prostate transmembrane protein, androgen-induced 1 (PMEPA1) has been previously shown to promote solid malignancies in a variety of cancers, but the role and mechanisms of PMEPA1 in breast cancer has not been fully addressed. Here, we found that PMEPA1 was upregulated in breast cancer cell lines as well as in a set of clinical invasive breast ductal carcinomas. Interestingly, depletion of PMEPA1 decreased breast cancer stem cell (CSC)-enriched populations, while ectopic overexpression of PMEPA1 increased breast CSC-enriched populations. Furthermore, transforming growth factor-β (TGF-β) treatment was also found to upregulate PMEPA1 expression and the CSC-enriched populations in triple-negative breast cancer cell lines. TGF-β-induced PMEPA1 expression partially contributed to TGF-β-induced breast CSC maintenance. These findings suggest that TGF-β-PMEPA1 axis might provide new diagnosis and therapeutic targets for breast cancer treatment.

 

Keywords   PMEPA1; TGF-β; cancer stem cell

 

Received   2015-8-1  
Accepted  
2015-9-21

 

Funding  This study was supported by the grants from the National Natural Science Foundation of China (Nos. 81272930, 81322038, 31260208, 81460401, and U1132605), Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Me

 

* Correspondence address  Tel: +86-871-65324888; Fax: +86-871-65336015; E-mail: [email protected] (D.W.)/Tel: +86-871-5181945; Fax: +86-871-65181945; E-mail: [email protected] (R.L.)

 
Browse:201
 
Manuscript Submission

    ScholarOne Manuscripts

User ID

Password

           

    Password Help

E-Mail

 
 
Copyright 1999-2016 Acta Biochimica et Biophysica Sinica All Rights Reserved
Address: Room 407, Building 31B, 319 Yueyang Road, Shanghai, 200031 P.R. China
Fax: 86-21-54920954 Email: [email protected]
 
沪ICP备05033115号 |  您是第 位访问者,欢迎!