Abstract
 
Vol 48 No. 3: 209-219 [PDF] [Full Text]
 
The involvement of N-methyl-D-aspartate receptor (NMDAR) subunit NR1 in the pathophysiology of schizophrenia
 
Peijun Ju and Donghong Cui*
 
Shanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai 201108, China
 

Abstract  Schizophrenia is a severe mental illness that afflicts nearly 1% of the world population. Although the exact pathophysiology of schizophrenia is unknown, the N-methyl-d-aspartate receptor (NMDAR), a major glutamate receptor subtype, has received great attention. The NR1 subunit is often considered indispensable for functional NMDAR assemblies, abnormal modulation of which is found in patients with schizophrenia. In this review, we discuss how disrupted function of NR1 subunits in NMDAR leads to the progression and development of symptoms of schizophrenia-like behaviors in a variety of genetically modified mouse models. We also discuss some of the susceptible genes and shared signaling pathways among the schizophrenia, and how their mutations lead to NR1 subunits hypofunction. Finally, we suggest that the subunit-selective modulators of NR1 subunits in NMDA receptors may be promising tools for the therapy of schizophrenia.

 

Keywords   NR1 subunits; NMDA receptor; schizophrenia

 

Received   2015-5-25  
Accepted  
2015-10-26

 

Funding  This work was supported by the grants from the Natural Science Foundation of Shanghai, China (No. 14ZR1435900), Qihang Personnel Training Program of Shanghai Mental Health Center (No. 2013-QH-01 & 2013-QH-01-X), the National Natural Science Foundation of

 

* Correspondence address  Tel/Fax: +86-21-64901737-2572; E-mail: [email protected]

 
Browse:246
 
Manuscript Submission

    ScholarOne Manuscripts

User ID

Password

           

    Password Help

E-Mail

 
 
Copyright 1999-2016 Acta Biochimica et Biophysica Sinica All Rights Reserved
Address: Room 407, Building 31B, 319 Yueyang Road, Shanghai, 200031 P.R. China
Fax: 86-21-54920954 Email: [email protected]
 
沪ICP备05033115号 |  您是第 位访问者,欢迎!