Raman Spectra of Porous
β-TCP Bioceramics Implanted into Rabbit Femur
HE Ji-Ping1,YOU Nai-Ting2, CHEN Qin3,
HU Xiao-Ning4, ZHENG Qi-Xin5, LI Shi-Pu6 and
Squire Jason2
( 1Centre for Material Research and Analysis, Wuhan University of
Technology, Wuhan 430070, China; 2Department of Chemistry, the
Hong Kong University of Science and Technology, Hong Kong, China; 3The
Second Affiliated Hospital of Hubei Medical University, Wuhan 430071, China;
4Shanghai Institute of Technical Physics, the Chinese Academy of
Sciences, Shanghai 200083, China; 5 Xiehe Hospital,
Tongji Medical University, Wuhan 430022, China; 6Biomedical
Materials and Engineering Centre, Wuhan University of Technology, Wuhan
430070, China )
Abstract The Raman spectra of porous
β-TCP(β-tricalcium phosphate)bioceramics implanted into rabbits femur, the
boundary and rabbit femur were studied using Raman spectroscopy(excited with
514.5nm and 623.8nm laser)and near-infrared FT-Raman spectroscopy. The Raman
characteristic frequencies were assigned. The advantages and disadvantages of
visible and near IR excitation are described. The Raman characteristic
frequencies of calcium phosphate, collagen, protein and lipid(or
phospholipid)were shown in the Raman spectra. These results demonstrated that
besides calcium phosphate, collagen, protein and lipids also existed in the
implants and the boundary, forming components of organic bone tissues. Results
indicated that the β-TCP bioceramic, when implanted into rabbit femur, was
partly dissolved and degraded, the new bone tissues were formed on the surface
and in pores of implanted bioceramics.
Key Words β-Tricalcium phosphate(β-TCP)bioceramics;
implanted into rabbit femur; Raman spectra
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