An Evolutionary Trace Method for
Functional Prediction of Genomes
XIE Tao,CHEN Jie and DING Da-Fu
( Shanghai Institute of Biochemistry,the Chinese Academy of
Sciences,Shanghai 200031,China )
Abstract It is essential for functional
genomics to develop an accurate and efficient functional prediction method of
genomes.Here,a new method is suggested,that is based on the fact that
ortholog-specific motif is an evolutionary trace,in which the functional
prediction of genomics is carried out.First,orthologous sets in a family were
constructed using evolutionary analysis；then functional motifs for
each orthologous set were found out and a database consisted of these motifs
was built.When this database is completed,unknown genes can be predicted
accurately and quickly by searching it.The pilot study on five families proves
that our method is feasible.
Key Words Genome functional prediction；evolutionary trace；functional motif
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