The Feasibility of Using Proteome
Expression Profile for Genome Annotation
XIE Tao,SHENG Quan-Hu and DING Da-Fu
( Shanghai Institute of Biochemistry,the Chinese Academy of
Sciences,Shanghai 200031,China )
Abstract By investigating into the
expression data from ECO2DBASE (Edition 6),the feasibility of using proteome
expression profile for genome annotation was tested.Based on our newly
developed CRC (cellular role cluster) method,79 proteins extracted from
ECO2DBASE were clustered into 4 CRCs.Function related proteins tend to be
clustered into same CRC.Total 9 aminoacyl-tRNA synthetases were clustered into
CRC2,whereas 4 heat-shock proteins into CRC3.These results indicate：with enough proteome
expression data and the efficient algorithm,proteome expression profile can
provide very important information for genome annotation,while this kind of
information is sequence-independent.
Key Words Proteome；expression profile；genome annotation；CRC(cellular role cluster)
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