The Relationship between
Yeast Coexpressed Gene Clusters and Their Upstream cis-acting
Elements
XIE Tao, SHENG Quan-Hu and DING Da-Fu
( Shanghai Institute of Biochemistry, the Chinese Academy of Sciences,
Shanghai 200031, China )
Abstract DNA
microarrays bring biology a new approach to study functions of genes and
genomes from their expression pattern on a genomic scale. With its fully
sequenced genome and newly published expression patterns available, budding
yeast (Saccharomyces cerevisiae) was chosen to carry out an
investigation of the relationship between gene 5′ upstream cis-acting
elements and expression patterns using bioinformatic tools. Results show that
genes in the same cluster share common cis-acting element candidates
and can be regulated by same transfactors. In the sites found by this study,
some sites are corresponding to known cis-acting elements, while
others may indicate new ones that can be tested by experiments. The results are
helpful to understand more about gene functions, metabolic pathways and genetic
networks.
Key Words cis-acting element； DNA microarray； genome annotation； expression pattern
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