Progress in the Research
of Plasminogen Activator Inhibitor Type-2
HU Jin-Yong, SANG Yu-Ying, ZENG Ying*
( Plant Biotechnology Department, Kunming Institute of Botany, the Chinese
Academy of Sciences, Kunming 650204, China )
Abstract Plasminogen
activator inhibitor type-2 (PAI-2) inhibits urokinase type plasminogen
activator (u-PA) most specifically and high efficiently, following the
mechanism of serine proteinase inhibitor (serpin) superfamily. PAI-2 plays a
very important role in
vivo； there are, however, two
conflicting views on the role of PAI-2 in cancer. Tissue-type plasminogen
activator, vitronectin, transglutaminases, fibrin and many other molecules can
interact with PAI-2. Regulation factors of PAI-2 gene expression includes
many regulatory elements in the promoter region, a number of agonists and
conditions of organism, etc., showing that PAI-2 gene is
regulated by both positive and negative mechanisms.
Key words PAI-2； mechanism； function； gene regulation
Received:
November 12, 1999 Accepted: January 26, 2000
This work was supported by a grant from the Natural Sciences
foundation of Yunnan Province, No. 1999C0077M
* Corresponding author: Tel, 86-871-5150660-3115; Fax,
86-871-5150227; e-mail, [email protected]