Influence of An
Adenosine Receptor Antagonist on Neurotransmitters in Parkinsonian Mice
YUAN Chong-Gang*, XUE Xiao-Lin, HE Ling
( East China Normal University, Shanghai 200062, China )
Abstract The effects
of the adenosine A2a receptor antagonist, Quinazoline, on the
monoamine transmitters NA, DA, 5-HT and 5-HIAA was studied using fluorecent
method, and the influence of MPTP(1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine)
and Quinazoline (CP66713) on the GABA positive reaction cells in globus
pallidus was determined by immunohistochemistry technique in MPTP treated
Parkinsonian mice. The results showed that MPTP decreased the content of DA,
5-HIAA and increased 5-HT, GABA obviously(p<0.05,p<0.01).
Quinazoline functioned opposite the action of MPTP, increasing the content of
DA, 5-HIAA and decreasing the 5-HT. Quinazoline also reduced the GABA-positive
reaction cells in globus pallidus of control mice and maintained the level of
GABA-positive reaction cells of globus pallidus in MPTP treated mice, making it
similar with the level of control.
Key words adenosine receptor antagonist；Parkinsonian mouse；neurotransmitter；MPTP
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