A
Evolutionary Approach to Identification of Orthologous Relationship Across Proteomes
SHI Shuo-Yong, DING Da-Fu
( Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, the Chinese
Academy of Sciences, Shanghai 200031,
China )
Abstract How to
identify the true orthologous and paralogous relationships among protein
families is still a key problem in genome annotation and comparative protemics.
Here, a evolutionary approach to ascertainment of the orthologous relationships
across the genomes is developed. Forty-four cases of protein families are used
in the test for the evolutionary approach. Compared with the method of COG
(cluster of orthologous groups of proteins), this approach can generally
identify the orthologous relationships and accurately predict the genome
function.
Key words ortholog; paralog; evolutionary analysis;
comparat
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