Interaction
between HTLV-1 Transcription Activator Tax and Taxreb107
YANG Xi, WANG Ji-Shu, HAN Hua*
( Department of Medical Genetics and Developmental Biology, The Fourth Military Medical
University, Xi’an 710032,
China )
Abstract Tax is a
transcription activator encoded by human T-cell leukemia virus (HTLV)-1.
Ribosomal protein L6 was also defined as Taxreb107 (Tax responsible element
binding protein 107) for its activity of binding to the long terminal repeats
of HTLV-1. To investigate the relationship between Tax and Taxreb107/RpL6, yeast two hybrid and GST pull-down assays
were used. Results suggest that Tax can interact with Taxreb107/RpL6 directly
and Taxreb107/RpL6 may regulate the function of Tax in HTLV-1 proliferation.
Key words Tax; Taxreb107/RpL6; HTLV-1; yeast two
hybrid
*Corresponding author:
Tel, 86-29-3374487; e-mail, [email protected]