The Human α2A–AR
Gene and the Genotype of Site -1296 and the Susceptibility to Motion Sickness
LIU Li*, YUAN Li1, WANG
Hong-Bo,YU Li-Shen2, ZHENG Jun, LUO Chao-Quan1, WANG Ye
( Key Laboratory of Molecular Biology, General Hospital of Airforce, Beijing 100036,China;1Department
of Biochemistry,Sun Yat-Sen University of Medical Sciences,Guangzhou 510089,China;2Institute
of Aviation Medicine AF,Beijing 100036,China )
Abstract The gene
sequences of α2A-adrenergic receptor (α2A-AR) in 39
Chinese and 1 Englishman showed 13 differences of g or c insertion or deletion
in its regulation region, coding region and 3′ untranslated region, compared
with that reported in GenBank.The gene sequences from all the samples
respectively were identical except for 2 single nucleotide polymorphisms, including the sequence of sense and
antisense strand sequenced. It was
found that: (1) the frequency of gg genotype in Chinese and Japanese,who are
high susceptible to motion sickness,were 5.8 and 7.8 fold higher than that in
Englishmen; (2) g allele frequencies in Chinese and Japanese were higher than
latter ( P＜0.01 ); (3) gg genotype frequency in
population susceptible to motion sickness was 1.6 fold higher than that in
population unsusceptible to motion sickness, and g allele frequency was higher
than latter (P＜0.01). All the populations were in
Hardy-Weinberg equilibrium.The results suggested that gg genotype and g allele
at site -1296 in α2A-AR gene could associate with the
susceptibility to motion sickness.
Key words α2A adrenergic recepror (α2A-AR);
gene; polymorphism; motion
sickness
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