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ISSN 0582-9879 Acta Biochimica et Biophysica Sinica 2004, 36(7): 443–449 CN 31-1300/Q
Inositol and Phosphatidylinositol Mediated Glucose Derepression,
Gene Expression and Invertase Secretion in Yeasts
Zhen-Ming CHI*, Jun-Feng LI, Xiang-Hong WANG, and Shu-Min YAO
UNESCO Chinese Center of Marine
Biotechnology, Ocean University of China, Qingdao 266003, China
Abstract Glucose repression occurs in many yeast species and some filamentous
fungi, and it represses the expression and secretion of many intracellular and
extracellular proteins. In recent years, it has been found that many
biochemical reactions in yeast cells are mediated by phosphatidylinositol
(PI)-type signaling pathway. However, little is known about the relationships
between PI-type signaling and glucose repression, gene expression and invertase
secretion in yeasts. Many evidences in our previous studies showed that glucose
repression, invertase secretion, gene expression and cell growth were mediated
by inositol and PI in Saccharomyces and Schizosaccharomyces. The
elucidation of the new regulatory mechanisms of protein secretion, gene
expression and glucose repression would be an entirely new aspect of inositol
and PI-type signaling regulation in yeasts.
Key words glucose repression;
PI-type signaling pathway; invertase secretion; gene expression
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Received: March 8, 2004 Accepted: May 18, 2004
This study was supported by a grant from the National Natural
Science Foundation of China (No. 30370015)
*Corresponding author: Tel, 86-532-2032266; Fax, 86-532-2032266;
E-mail, [email protected]