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ISSN
1672-9145
Acta Biochim Biophys Sin
2004, 36(9): 597–602
CN 31-1940/Q
Association between Alcohol, Smoking and HLA-DQA1*0201 Genotype in
Psoriasis
Guang-Yong ZHENG1,2#, Sheng-Cai WEI3#, Tie-Liu
SHI1, and Yi-Xue LI1*
1Bioinformatics
Center, Shanghai Institutes for Biological Sciences, Chinese Academy of
Sciences, Graduate School of the Chinese Academy of Sciences, Shanghai 200031,
China; 2Research Center for Proteome Analysis, Institute of
Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences,
Chinese Academy of Sciences, Graduate School of the Chinese Academy of
Sciences, Shanghai 200031, China; 3Guangzhou Institute of
Dermatology, Guangzhou 510095, China
Abstract Psoriasis is a chronic skin disease triggered
by genetic, environment or other risk factors such as infection, drugs, stress,
moisture, alcohol, and smoking. A major psoriasis susceptibility locus at
6p21.3 has been identified. Further studies found that HLA-DQA1*0201 allele was
associated with psoriasis. However, there were few data exploring an
association between the environmental factors and susceptibility genes. In this
study, the samples of 189 patients with psoriasis and 333 healthy controls were
collected with their consent and were carried on analysis through polymerase
chain reaction sequence-specific primer (PCR-SSP) method. The proportion of
male psoriasis patients engaging in the smoking and alcohol was much higher
than that of the control group (P<0.005). The HLA-DQA1*0201 allele
was present at significantly higher frequency in the patients with psoriasis
(OR=4.25, P<1.0×10–6). Association was found
between smoking, alcohol and HLA-DQA1*0201 in male patients with psoriasis
(OR>6.91, P<1.0×10–4).
Key words psoriasis; HLA-DQA1*0201 allele; smoking; alcohol; association
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Received: June 9, 2004 Accepted: July 22,
2004
This work was supported by the grants from the High-Tech Research
and Development Program of China (No. 2003AA231011) and the National Basic
Research Program of China (No. 2003CB715901, No. 001CB510209)
#These authors contributed equally to
this work
*Corresponding author: Tel, 86-21-54920089; Fax, 86-21-54920089;
E-mail, [email protected]