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ISSN
1672-9145
Acta Biochim Biophys Sin
2005, 37(4): 276–282
CN 31-1940/Q
Postnatal Developmental Expression of Calbindin, Calretinin and
Parvalbumin in Mouse Main Olfactory Bulb
Zhao-Ping QIN*, Shu-Ming YE,
Ji-Zeng DU, and Gong-Yu SHEN
Department of
Biology, College of Life Science, Zhejiang University, Hangzhou 310027, China
Abstract The distribution of calbindin, calretinin and parvalbumin during the
development of the mouse main olfactory bulb (MOB) was studied using
immunohistochemistry techniques. The results are as follows: (1)
calbindin-immunoreactive profiles were mainly located in the glomerular layer,
and few large calbindin-immunoreactive cells were found in the subependymal
layer of postnatal day 10 (P10) to postnatal day 40 (P40) mice; (2) no
calbindin was detected in the mitral cell layer at any stage; (3)
calretinin-immunoreactive profiles were present in all layers of the main
olfactory bulb at all stages, especially in the olfactory nerve layer, glomerular
layer and granule cell layer; (4) parvalbumin-immunoreactive profiles were
mainly located in the external plexiform layer (except for P10 mice); (5)
weakly stained parvalbumin-immunoreactive profiles were present in the
glomerular layer at all stages; and (6) no parvalbumin was detected in the
mitral cell layer at any stage.
Key words calbindin; calretinin; parvalbumin; mouse; main olfactory bulb
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Received: December 5, 2004
Accepted: February 4, 2005
This work was supported by a grant from the
National Natural Science Foundation of China (30070190)
*Corresponding
author: Tel, 86-571-87951826; E-mail, [email protected]